| Paper: | PS-2B.24 |
| Session: | Poster Session 2B |
| Location: | Symphony/Overture |
| Session Time: | Friday, September 7, 19:30 - 21:30 |
| Presentation Time: | Friday, September 7, 19:30 - 21:30 |
| Presentation: |
Poster
|
| Publication: |
2018 Conference on Cognitive Computational Neuroscience, 5-8 September 2018, Philadelphia, Pennsylvania |
| Paper Title: |
Disinhibition as a canonical neural mechanism for flexible behavior |
| Manuscript: |
Click here to view manuscript |
| DOI: |
https://doi.org/10.32470/CCN.2018.1165-0 |
| Authors: |
Dominic Standage, Martin Pare, Gunnar Blohm, Queen's University, Canada |
| Abstract: |
Flexibility is a hallmark of human and animal behavior, but the context-dependent neural computations that generate flexible behavior are poorly understood. Here, we use a biophysically-based cortical network model to explore the hypothesis that vasoactive intestinal polypeptide (VIP) expressing inhibitory interneurons control local circuit dynamics by targeting other classes of inhibitory interneuron, supporting context-dependent computations. Depending on the strength of this disinhibition (simulating VIP activity), network dynamics support multiple-item working memory (WM, strong disinhibition) or decision making (DM, weak disinhibition). Within these regimes, disinhibition controls WM capacity and speed-accuracy-trade-off in choice behavior. Our findings suggest that long-range trans-cortical VIP-mediated disinhibition is a canonical neural mechanism for the top-down control of flexible behavior. |
